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pentobarbital will lessen the extent or result of buprenorphine, prolonged-acting injection by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Sufferers who transfer to buprenorphine extensive-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers should be monitored to be sure